Prion Strain Discrimination Based on Rapid In Vivo Amplification and Analysis by the Cell Panel Assay
نویسندگان
چکیده
منابع مشابه
Prion Strain Discrimination Based on Rapid In Vivo Amplification and Analysis by the Cell Panel Assay
Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mice the four prion strains examined are rapidly and faithfully amplified and can subsequently be di...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0005730